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Join us at a location near you to meet our experts and product specialists, and learn out how the latest technical innovations can improve both the efficiency and quality of your processes at all scales.
November 2017
Pharmtech 2017

医薬品製造, Crocus Expo IEC, Moscow

Join us at the Pharmtech exhibition to discover our most recent advances in continuous bioprocessing. Visit us at booth #A429, Hall 7, for a week of expert knowledge, cutting-edge technology and critical learning, all delivered with news of the latest industry trends and breakthroughs in science and technology.
 

Pharmtech & Ingredients is the largest international exhibition in Russia and the CIS presenting equipment, raw materials and technologies for manufacturing pharmaceutical products, nutritional supplements, blood products and cosmetics. It gives companies – producers and suppliers – a unique opportunity to present modern production and packaging equipment, laboratory equipment, projects and technological solutions for turnkey pharmaceutical manufacturing, for cleanrooms and for clinical trials conduction.

The Ingredients sector is intended to reflect the increased role of high quality active pharmaceutical ingredients and functional ingredients for producing modern medicines.

Pall has turned continuous bioprocessing theory into reality. Only Pall has the Continuous Ready products and integration expertise that has made Continuous Bioprocessing a reality. They enable bioprocessors to achieve the highest product quality, productivity and patient benefit with a dramatically smaller footprint and shorter lead times.

We look forward to meeting you!

Products Featured
Cadence Acoustic Separator
Kleenpak® Presto Sterile Connector
Cadence™ Inline Concentrator
iCELLis® Bioreactor

Leadership Forum on Bioprocess Intensification

医薬品製造, DoubleTree by Hilton Hotel, Westborough, MA

Pall Life Sciences invites you to join industry leaders for two days of expert knowledge, cutting-edge technology and critical learning. All delivered with industry case studies, latest industry trends and breakthroughs in science and technology.

AGENDA


Tuesday, November 14th

12:00 pm - 1:30 pm

Registration and Networking Lunch
 

1:30 pm -1:40 pm

Welcome and Introduction
 

1:40 pm - 2:10 pm

‘An Update on Significant Technology Advances Enabling Integrated Continuous Bioprocessing’
 

2:10 pm - 3:55 pm

‘Making a Business Case for Integrated Process Technology’
 

3:55 pm -4:25 pm

Break – Posters
 

4:25 pm - 6:10 pm

Workshop: 3 Technology Sessions Running in Parallel (40 Minutes/Workshop)
 

6:10 pm - 6:20 pm

Summary and End of Day 1
 

7:15 pm

Departure from DoubleTree Hotel
 

7:45 pm

Dinner
 

11:00 pm

Return to DoubleTree Hotel


Wednesday, November 15th

8:15 am - 8:30 am
Welcome

8:30 am - 10:15 am

‘Experiences About Processing and Technology Challenges From Batch to Continuous’
 

10:15 am - 10:45 am

Break – Posters
 

10:45 am - 2:30 pm

Roundtable - Applying ICH Q8/Q9 to Continuous Processing
 

12:30 pm - 13:00 pm

Drivers for an Evaluation of Continuous Capture Chromatography at KBI Biopharma
 

13:00 pm - 13:05 pm

Event Summary and Closing
 

13:05 pm - 14:30 pm

Networking Lunch
 


Download the full agenda

Swiss Cleanroom Concept

医薬品製造, Courtyard Marriott, PratteIn

Join us at this event to discover our total mixing solutions at this Swiss Cleanroom Community Event, the meeting place of the GMP and cleanroom sectors, held twice a year for knowledge transfer, product information and networking. The education and networking in this stimulating atmosphere are the success of the event.

We will take this opportunity to present you our total mixing solutions - a critical operation within many biopharmaceutical processes for applications ranging from buffer and media preparation, in-process unit operations such as low pH viral inactivation to final formulation.

Pall provides the broadest range of single-use mixers, covering all potential applications and requirements. Our magnetic drive technologies (Magnetic and LevMixer® units) represent the foundation of the largest installed base of mixing technology globally.

With our automation expertise and complementary technologies such as the Pall powder transfer bags and the Allegro™ MVP system, we can provide full automation around mixing applications with our standard systems, or customized solutions. 


We look forward to meeting you!

Products Featured
Single-Use Mixers

October 2017

Join us during this day of professional growth, discussion and update on the main trend of Advanced Therapy Medicinal Products.


Agenda

  • Developing T-cell therapy program
  • “Hospital Exemption”
  • Neural stem cells in MS: from bench to bedside
  • CAR-T industrialization
  • Clinical applications of MSCs in HSCT and beyond
  • Latest advances for CARCIK.CD19 clinical protocol
  • Bioreactors for viral vectors manufacturing
  • Regulatory perspective



13:00 – 14:00

Presentation: Lentiviral/Retroviral Vector Manufacturing Production using iCELLis® Disposable Fixed-Bed Bioreactor iCELLis System"
Manuela Cota, Upstream Vector Development Supervisor, MolMed S.p.a. (Italy)


Abstract
Lentiviral vectors (LVV), produced with transient quadri-transfection in 293T adhesion cell line and retroviral vectors (RVV), produced with a stable packaging cell line, are used in gene therapy studies. In the context of advanced clinical studies or commercial phase, an important manufacturing challenge is the optimization of vector production in large-scale platforms. To address this issue and to obtain a scalable and robust process, development studies were performed using iCELLis fixed-bed disposable bioreactors. 

The optimized parameters included seeding cell density, DNA concentration, transfection agents, timing and volumes of harvest. Final vectors were characterized for infectious viral titer (TU/mL), particle content (ng p24 or ng p30), process related impurities and then compared to vectors produced by current GMP processes based on Cell Factories (CFs).

Productivity was 5.7 x 106 TU/mL with an infectivity of 6 x 104 TU/ng p30 and 3.1 x 107 TU/mL with an infectivity of 8 x 104 TU/ng p24 for RVV and LVV, respectively. Productivity using bioreactors was higher than that obtained in GMP CFs based processes while impurities profiles (BSA, HCD, HCP) were overall comparable. Vectors manufactured in bioreactor were used to transduce primary cells (CD34+ and T cells) showing high transduction efficiency and vector copy number. Although the downstream process currently in use for GMP LVV production can be successfully applied to vectors produced in small scale bioreactors, a different strategy is under development to accommodate larger volumes. Preliminary data indicate the possibility to efficiently purify vectors with no detrimental impact on process performance, vector infectivity and stability.

 

Products Featured
iCELLis® Bioreactor
Xpansion® Multiplate Bioreactor System
PadReactor® Mini Bioreactor
SoloHill® Microcarriers 

The ESGCT Annual Meeting provides an opportunity for scientists, clinicians and industry professionals to share new data, learn from peers, and discover global advances within the Gene and Cell Therapy field. 

 

Pall's cell therapy technologies and services include powerful manufacturing platforms designed to help you overcome the challenges associated with producing live cells destined for therapeutics, and streamline your pathway to commercialization in these very exciting applications. 

 

Our business philosophy and culture are centered on helping our customers achieve their goals. Together, our combined expertise is advancing the development of cell therapies that will improve the lives of patients worldwide. 

 

We look forward to meeting you!

Products Featured
Xpansion® Multiplate Bioreactor System
iCELLis® Bioreactor
SoloHill® Microcarriers
Allegro™ Unison hMSCs and Media

June 2017
AFI Symposium

医薬品製造, Nuovo Palacongressi, Rimini, Italy

Mercoledì 7 Giugno dalle 9 alle 12 partecipa al nostro workshop “Verso una produzione in continuo, basata su unità integrate e modulari.” 

Lo sviluppo di specifiche tecnologie produttive, Continuous Ready Technology, unitamente agli intrinsechi benefici derivanti dalle tecnologie monouso, Single Use Technology, rendono possibile la transizione da produzioni batch a processi in continuo. La prossima frontiera per l’Industria Farmaceutica è rappresentata dall’adozione del processo in continuo su larga scala. Ciò rappresenterà l’ideale punto di arrivo di un rinnovamento che passa attraverso delle tappe intermedie: Single Use Facility - Process Intensification - Integrated Unit Operation - Continuous Process. 

 

Pall Products:

 

Richiedi un incontro con i nostri Specialisti e scoprire la nostra gamma di tecnologie Continuous Ready!

May 2017
Virus and TSE Safety Forum

医薬品製造, Sheraton Dubrovnik Riviera Hotel , Dubrovnik, Croatia

Join us at the Virus and TSE Safety Forum for three days of expert knowledge, cutting-edge technology and critical learning, all delivered with news of the latest industry trends and breakthroughs in science and technology.

 

Spend some time to ask our technical experts for advice on a range of process-related subjects, and engage with our presenters following a series of technology and market overview presentations which will take place on day two. During the event, Pall scientists will be presenting a series based on all-new technical data in the Poster and Exhibit Hall, so make sure to take some time to meet with them and discuss the results. You'll also get the chance to see a range of ground-breaking, class-leading new technologies and products.

 

Pall® Products Featured:

Kleenpak® Presto Sterile Connectors, Pegasus™ Prime Virus Removal Filters, Allegro™ Single-Use Filling Needles, Pyrofree♦ Vials

 

Just some of the reasons to see us at booth #16 or at presenter sessions and forums throughout the event. We look forward to meeting you!

ESACT 2017

医薬品製造, SwissTech Convention Center, Lausanne, Switzerland

Join us at the ESACT Meeting on May 15-17 at booth #1 to discover recent advances in Cell Culture Technologies. 

 

Spend some time to ask our experts for advice on a range of process-related subjects. You'll also get the chance to see a range of ground-breaking, class-leading new technologies and products.

 

Live Demos  

Did you know that our 1000 L Allegro™ STR1000 Single-Use Stirred-Tank Bioreactor can be easily installed in minutes?  We will demonstrate this live on our booth! 

 

- Monday May 15: 10.30-11.00 and 17.00-17.30

- Tuesday May 16: 10.30-11.00

- Wednesday May 17: 10.30-11.00

 

Poster Sessions in Exhibition Hall

We will be presenting a series based on all-new technical data in the Poster Sessions in Exhibition Hall, so make sure to take some time to meet with us and discuss the results.

 

Monday May 15 from 14.00 to 15.30

 

- Cost Modelling of Upstream Production Process of Lentiviral Vectors in HEK-293 Cells Comparing Multi-Tray 10 Stacks and Fixed-Bed Bioreactor - PO131

Presenter: Pascal Lefebvre – Global Product Manager, Pall Life Sciences - Belgium

 

- Acoustic Wave Separation – A Scalable Disruptive Technology for Continuous Clarification of Fed Batch Cell Culture Prior to Capture Chromatography - PO069

Presenter: Britta Badertscher – Technical Specialist, Pall Life Sciences - Switzerland

 

- A High-Throughput Cell Proliferation Assay For Screening Single-Use Materials For Cell Culture Compatibility - PO367

Presenter: Todd Sanderson – Senior Scientist, Pall Life Sciences - USA

 

Tuesday May 16 from 14.00 to 15.30

 

- Development of a Scalable Viral Vector Upstream Process for Gene Therapy: rAAV-8 Production by Transient Transfection of HEK-293 Cells in iCELLis® Bioreactor - PO350

Presenter: Pascal Lefebvre – Global Product Manager, Pall Life Sciences - Belgium

 

- Scalable Stem Cell Expansion Bioprocess using Single-Use, Fed-Batch Reactor Engineered for High Productivity - PO126

Presenter: Dave Splan - Principal Research Scientist, Pall Life Sciences - USA

 

- Engineering Characterization of the Allegro Stirred Tank Reactors for Successful Cell Culture Scale-Up - PO106

Presenter: Joe Capone - Global Product Manager, Pall Life Sciences - USA

 

Do not miss this opportunity to meet us!

 

Pall® Products Featured

 

Just some of the reasons to see us at booth #1 or at poster sessions throughout the event. We look forward to meeting you!

International Society for Cellular Therapy Annual Meeting 2017

医薬品製造, ExCel, London, London, UK

Product Theatre Presentation:

May 4: 13:00 – 13:30

 

Human mesenchymal stem cells (hMSC) represent the most highly utilized cell type for cell therapy and regenerative medicine applications. However, a major impediment to progress in the field is availability of sufficient numbers of high quality hMSC for process development studies. Given that large numbers of high quality cells are required for many applications and that large surface area requirement for cell expansion is necessary, a search for a practical manufacturing platform for hMSC expansion has been ongoing over the last decade.

We have developed a manufacturing platform that enables reproducible expansion of large numbers of high quality hMSC from fed-batch microcarrier cultures without the need for media exchanges or extensive process development. Expansion data generated with bone marrow derived hMSC using sterile microcarriers in single-use bioreactors reproducibly generated over twenty-fold expansion in 4 days. Cryopreserved hMSC seeded directly onto microcarriers in the PadReactor Mini bioreactor followed by transfer to a larger volume PadReactor System showed >200-fold expansion in only 8 days. Cells expanded using this platform and processes maintain critical quality and functional parameters. This single-use system and associated process can be used by others to generate billions of cells without the need for further development studies.

Presenter: Mark Szczypka - Senior Director, Single-Use Technologies, Process Development and Applications R&D, Scientific and Laboratory Services

 

Scientific Poster Presentations:
May 4: 17:00 - 18:30, Poster Session # 1 – Exhibit Hall

 

  • Development and Optimization of Large Scale Production of Adenoviral Vector and Autologous Insulin-Producing Cells Using iCELLis® 500 and Xpansion® 200 Single-Use Bioreactors
  • Industrialization of AdenoVirus Production and Purification with the iCELLis 500 Single-use Bioreactor
  • Rapid and Robust Large-Scale Expansion of High Quality Human Mesenchymal Stem Cells for Use in Regenerative Medicine Applications
  • Simple and Efficient Cell Harvest Methods for Microcarrier cultures in Bioreactors

Presenter: Mark Szczypka - Senior Director, Single-Use Technologies, Process Development and Applications R&D, Scientific and Laboratory Services



Presentation:
May 5: 15:30 – 17:00, Early Stage Professionals (ESP) Session 1 – Advanced Strategic Innovations for Cell & Gene Therapies



The focus of this session will be scientific innovation, presented by early stage professionals. The session will be wide ranging, with topics about manufacturing the world's largest therapeutic cell bank to CAR-T cells and viral vector engineering for transgene delivery. At the end of this session, participants should be able to identify what current advances are being made with CAR T cells, What options are available to scale up UC-MSCs, and recent approaches to engineering vector-based transgene delivery.

Presenter: Ben Weil, MRes, EngD, University College London

 

Pall® Products Featured:

April 2017

Join us to discover recent advances in Continuous Bioprocessing and learn how to manage accurate scale-up.

 

09:30 am: Coffee

 

10:00 am – 11:30 am: Presentations

1. Welcome

Eric Levacher, IMT Technical Manager and Galenic Development, and Guy Soubeyroux, Vice President, EMEA Sales, Pall Life Sciences

2. What does Continuous Bioprocessing Mean?

Nicole Fontourcy, Senior Marketing Manager, Pall Life Sciences

3. Monoclonal Antibodies and Biomedicaments Joan Leclerc, Project Manager, ARD2020 Biomedicaments Mélusine Larivière, Scientific Trainer, LabEx MabImprove

 

11:30 am – 1:30 pm: Visit to laboratories of Biocube Institute

12:30 pm: Buffet Lunch

 

1:30 pm: Workshops

 

- Cell Culture and Single-Use Bioreactors

Renaud Balsse, Bioreactor Specialist, Pall Life Sciences     

 

- How to optimise purification steps in a bioprocess? 

Meriem Bendouma, Biopurification Process Specialist, Pall Life Sciences

 

- How to Optimise Process Steps With Single-Use? 

Marie-Pierre Travers, Senior Single-Use Specialist, Pall Life Sciences

3:30 pm – 4:00 pm: Summary and Q&A

 

4:00 pm – 5:00 pm: Networking

 

Pall® Products Featured:

XRS 20 Bioreactor, Cadence™ Acoustic Separator, Kleenpak® Presto Connectors, Pegasus™ Prime Virus Removal Filters , Stax™ Disposable

Depth Filter Systems, Cadence™ Inline Concentrator, PRC Columns, Allegro™ 50 L Mixers, Palltronic® Flowstar LGR Test Instrument, Pyrofree Vials, Allegro Single-Use Filling Needles